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- People with pre-diabetes who drop substantial weight may ward off type 2 diabetes -- ScienceDaily
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DOI: Euglycemic diabetic ketoacidosis eu-DKA is a rare life-threatening complication associated with the use of SGLT2 inhibitor that may be unnoticed, particularly in a pandemic setting, due to the absence of significant hyperglycemia, delaying its treatment. In this report, we describe a case of a year-old patient who presented an elevated anion gap metabolic acidosis during a SARS-CoV-2 infection and was diagnosed with SGLT2-associated euglycemic diabetic ketoacidosis. COVID may increase patients' insulin demand, present gastrointestinal symptoms, and increase the production of ketone bodies. This situation can be worsened in susceptible diabetic patients on SLGT2 inhibitors, due to the persistent glycosuria, which can cause volume depletion.
N Engl J Med. Arq Bras Endocrinol Metab International diabetes federation: IDF diabetes atlas - 8th edition, American Diabetes Association. Prevention or delay of type 2 diabetes: standards of medical Care in Diabetes Classification and diagnosis of diabetes: standards of medical Care in Diabetes Prevalence of pre-diabetes across ethnicities: a review of impaired fasting glucose IFG and impaired glucose tolerance IGT for classification of Dysglycaemia.
Insights Nutr Metabol— The epidemic of pre-diabetes: the medicine and the politics. Efficacy and effectiveness of screen and treat policies in prevention of type 2 diabetes: systematic review and meta-analysis of screening tests and interventions.
Johns Hopkins Medicine Summary: People with pre-diabetes who lose roughly 10 percent of their body weight within six months of diagnosis dramatically reduce their risk of developing type 2 diabetes over the next three years, according to new research. Share: FULL STORY People with pre-diabetes who lose roughly 10 percent of their body weight within six months of diagnosis dramatically reduce their risk of developing type 2 diabetes over the next three years, according to results of research led by Johns Hopkins scientists. Substantial weight loss in the short term clearly should go a long way toward preventing diabetes. Uncontrolled diabetes -- marked by excess sugar in the blood -- can lead to eye, kidney and nerve damage, as well as cardiovascular disease. The new research suggests that if people with pre-diabetes don't lose enough weight in those first months, physicians may want to consider more aggressive treatment, such as adding a medication to push blood sugar levels lower.
Differences in A1C by race and ethnicity among patients with impaired glucose tolerance in the diabetes prevention program. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. Diabetes Prevention Program Research Group HbA1c as a predictor of diabetes and as an outcome in the diabetes prevention program: a randomized clinical trial.
Karve A, Hayward RA. Prevalence, diagnosis, and treatment of impaired fasting glucose and impaired glucose tolerance in nondiabetic U. Prevalence of prediabetes according to hemoglobin A1c versus fasting plasma glucose criteria in healthy adults.
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- Global epidemiology of prediabetes - present and future perspectives. - Abstract - Europe PMC
- Study uncovers why COVID is more deadly fo | EurekAlert!
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It found that type 2 diabetes is associated with a higher risk of mortality in hospitalised COVID patients than type 1 diabetes. The combination of an older age and high C-reactive protein CRP was also linked to a higher risk of death.